The purpose of this literature review is to evaluate the beneficial uses of medicinal marijuana while recognizing the current challenges related to access and use. The use of medicinal marijuana shows great promise in chronic and terminal disease treatments; however, its use and accessibility are entangled in regulation and politics. Studies have shown the use of medicinal marijuana dating back to 5000 BC (Bridgeman & Abazia, 2017) and its use has continued through modern-day. Limited scientific research is available to date. The research that has been conducted shows great potential for reduction in pain, complementary cancer treatments, a decrease in abuse of opioids, removal of black-market sales and drug trafficking, and a natural approach to managing one’s own health. Further studies must be conducted to better understand the use of medicinal marijuana and its effects on the body. This research should then be used to help guide legal regulation, physician prescribing practices, and consumer accessibility.